Z1

Administration and coordination of the CRC 1182

The main purpose of the Z1-project is to bundle the central activities of the Collaborative Research Centre 1182. The administrative office runs the daily affairs of the CRC 1182 including the management of funds, the coordination of CRC 1182 retreats, internal and external seminars with invited speakers, CRC 1182 symposia and other CRC 1182-related activities including establishment of a CRC 1182 homepage. The office is also responsible for coordination of all activities for the early career researchers as well as organization and coordination of gender equality issues.

Researchers

Publications

2017

Back to the Basics: Cnidarians Start to Fire.

Bosch T C, Klimovich A, Domazet-Lošo T, Gründer S, Holstein T W, Jékely G, Miller D J, Murillo-Rincon A P, Rentzsch F, Richards G S, Schröder K, Technau U, Yuste R (2017); Trends Neurosci., 40(2):92-105. doi: 10.1016/j.tins.2016.11.005

2016

FRT – FONDATION RENE TOURAINE: An International Foundation For Dermatology.

Bosch T C, Zengler K, Naik S, Biedermann T, Kong H H, Loser K, Brüggeman H, Calleawert C, Lambert J, Van de Wiele T (2016); Exp Dermatol., 25(11):917-932. doi: 10.1111/exd.13160

The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra.

Schröder K, Bosch T C (2016); MBio., 7(6):e01184-16. doi: 10.1128/mBio.01184-16

Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model.

Deines P, Bosch T C G (2016); Front. Microbiol., 7:1610. doi: 10.3389/fmicb.2016.01610

Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics.

Gilson E, Bosch T C G (2016); Meeting report on “Comparative Biology of Aging”, Roscoff, October 12-16, 2015. BioEssays, 38(6):494-97. doi: 10.1002/bies.201600049

Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes.

Theis K R, Dheilly N M, Klassen J L, Brucker R M, Baines J F, Bosch T C, Cryan J F, Gilbert S F, Goodnight C J, Lloyd E A, Sapp J, Vandenkoornhuyse P, Zilber-Rosenberg I, Rosenberg E, Bordenstein S R (2016); mSystems., 1(2).pii:e00028-16. doi: 10.1128/mSystems.00028-16

The Holobiont Imperative.

Bosch T C G and D Miller (2016); Springer New York, ISBN: 978-3-7091-1894-8

2015

Revisiting the age, evolutionary history and species level diversity of the genus Hydra (Cnidaria: Hydrozoa).

Schwentner M, Bosch T C (2015); Mol Phylogenet Evol., 91:41-55. doi: 10.1016/j.ympev.2015.05.013

Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents.

Gilbert S F, Bosch T C, Ledón-Rettig C (2015); Nat Rev Genet., 16(10):611-622. doi: 10.1038/nrg3982

Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance

Fraune S, Franzenburg S, Schröder S, Augustin R, Anton-Erxleben F, Bosch TCG. (2015); ISME Journal, 9:1543–1556. doi: 10.1038/ismej.2014.239

Which games are growing bacterial populations playing?

Li XY, Pietschke C, Fraune S, Altrock PM, Bosch TC, Traulsen A (2015); J R Soc Interface., 12(108). doi: 10.1098/rsif.2015.0121

Microbial ecology in Hydra: Why viruses matter.

Bosch T C G, Grasis J A, Lachnit T (2015); J Microbiol, 53(3):193-200. doi: 10.1007/s12275-015-4695-2

Microbial ecology in Hydra: Why viruses matter.

Bosch T C, Grasis J, Lachnit T (2015); The Journal of Microbiology, 53(3):193-200. doi: 10.1007/s12275-015-4695-2

Hydra and the evolution of stem cells.

Klimovich A, Böhm A M, Bosch T C G (2015); „Stem cell biology and regenerative medicine” River Publishers, 113-136. ISBN: 9788793237070

2014

How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans.

Bosch T C, Adamska M, Augustin R, Domazet-Loso T, Foret S, Fraune S, Funayama N, Grasis J, Hamada M, Hatta M, Hobmayer B, Kawai K, Klimovich A, Manuel M, Shinzato C, Technau U, Yum S, Miller D J(2014); Bioessays., 36(12):1185-94. doi: 10.1002/bies.201400065

Species-specific viromes in the ancestral holobiont Hydra.

Grasis J A, Lachnit T, Anton-Erxleben F, Lim Y W, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer F L, Bosch T C (2014); PLoS One., 9(10):e109952. doi: 10.1371/journal.pone.0109952

Rethinking the role of immunity: lessons from Hydra

Bosch T C G (2014); Trends Immunol., 35(10):495-502. doi: 10.1016/j.it.2014.07.008

Naturally occurring tumors in the basal metazoan Hydra.

Domazet-Lošo T, Klimovich A, Anokhin B, Anton-Erxleben F, Hamm M, Lange C, Bosch T C G (2014); Nat Communications, 5:4222. doi: 10.1038/ncomms5222

Regulation of polyp-to-jellyfish transition in Aurelia aurita.

Fuchs B, Wang W, Graspeuntner S, Li Y, Insua S, Herbst E M, Dirksen P, Bohm A M, Hemmrich G, Sommer F, Domazet-Loso T, Klostermeier U C, Anton-Erxleben F, Rosenstiel P, Bosch T C, Khalturin K (2014); Curr Biol, 24(3):263-273. doi: 10.1016/j.cub.2013.12.003

2013

Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.

Franzenburg S, Fraune S, Altrock P M, Künzel S, Baines J F, Traulsen A, Bosch T C G (2013); ISME J., 7(4):781-90. doi: 10.1038/ismej.2012.156

Distinct antimicrobial peptide expression determines host species-specific bacterial associations

Franzenburg S, Walter J, Künzel S, Wang J, Baines J F, Bosch T C G, Fraune S (2013); Proc Natl Acad Sci USA, 110(39):E3730-8. doi: 10.1073/pnas.1304960110

Animals in a bacterial world, a new imperative for the life sciences.

McFall-Ngai M, Hadfield M, Bosch T C G, Carey H, Domazet-Loso T, Douglas A, Dubilier N, Eberl G, Fukami T, Gilbert S, Hentschel U, King N, Kjelleberg S, Knoll A, Kremer N, Mazmanian S, Metcalf J, Nealson K, Pierce N, Rawls J, Reid A, Ruby E, Rumpho M, Sanders J, Tautz D, Wernegreen J (2013); Proc Natl Acad Sci USA, 110(9):3229-36. doi: 10.1073/pnas.1218525110

2012

Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.

Fraune J, Alsheimer M, Volff JN, Busch K, Fraune S, Bosch T C G, Benavente R (2012); Proc. Natl. Acad. Sci. USA, 109:16588-16593. doi: 10.1073/pnas.1206875109

MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers.

Franzenburg S, Fraune S, Künzel S, Baines J F, Domazet-Loso T, Bosch T C G (2012); Proc Natl Acad Sci USA, 109(47):19374-9. doi: 10.1073/pnas.1213110109

FoxO is a critical regulator of stem cell maintenance and immortality in Hydra.

Boehm A M, Hemmrich G, Khalturin K, Puchert M, Anton-Erxleben F, Wittlieb J, Klostermeier U C, Rosenstiel P, Oberg H H, Bosch T C G (2012); Proc Natl Acad Sci USA, 109(48):19697-702. doi: 10.1073/pnas.1209714109

MyD88 deficient Hydra reveal an ancient function of TLR-signaling in sensing bacterial colonizers.

Franzenburg S, Fraune S, Künzel S, Baines J F, Domazet-Loso T, Bosch T C (2012); Proc Natl Acad Sci U S A., 109(47):19374-9. doi: 10.1073/pnas.1213110109

Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1.

Sommer F, Awazu S, Anton-Erxleben F, Jiang D, Klimovich A V, Klimovich B V, Samoilovich M P, Satou Y, Krüss M, Gelhaus C, Kürn U, Bosch T C, Khalturin K (2012); Mol Biol Evol., 29(10): 3081-3093. doi: 10.1093/molbev/mss120

Where simplicity meets complexity: hydra, a model for host-microbe interactions.

Augustin R, Fraune S, Franzenburg S, Bosch T C (2012); Adv Exp Med Biol., 710:71-81. doi: 10.1007/978-1-4419-5638-5_8

2011

Embryo protection in contemporary immunology: Why bacteria matter.

Fraune S, Augustin R, Bosch T C (2011); Commun Integr Biol., 4(4):369-72. doi: 10.4161/cib.4.4.15159

2010

In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides

Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP, Bosch TCG (2010); Proc. Natl. Acad. Sci., 107(42):18067-18072. doi: 10.1073/pnas.1008573107

Why bacteria matter in animal development and evolution.

Fraune S,Bosch T C G (2010); Bioessays, 32(7):571-80. doi: 10.1002/bies.200900192

The dynamic genome of Hydra.

Chapman J A, Kirkness E F, Simakov O, Hampson S E, Mitros T, Weinmaier T, Rattei T, Balasubramanian P G, Borman J, Busam D, Disbennett K, Pfannkoch C, Sumin N, Sutton G G, Viswanathan L D, Walenz B, Goodstein D M, Hellsten U, Kawashima T, Prochnik S E, Putnam N H, Shu S, Blumberg B, Dana C E, Gee L, Kibler D F, Law L, Lindgens D, Martinez D E, Peng J, Wigge P A, Bertulat B, Guder C, Nakamura Y, Ozbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang J S, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz P R, Zhang X, Aufschnaiter R, Eder M K, Gorny A K, Salvenmoser W, Heimberg A M, Wheeler B M, Peterson K J, Böttger A, Tischler P, Wolf A, Gojobori T, Remington K A, Strausberg R L, Venter J C, Technau U, Hobmayer B, Bosch T C G, Holstein T W, Fujisawa T, Bode H R, David C N, Rokhsar D S, Steele R E (2010); Nature, 464:592-6. doi: 10.1038/nature08830

How Hydra senses and destroys microbes.

Augustin R , Fraune S, Bosch T C (2010); Semin Immunol., 22(1):54-8. doi: 10.1016/j.smim.2009.11.002

2009

Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota.

Fraune S, Abe Y, Bosch T C G (2009); Environ. Microbiol., 11(9):2361-2369. doi: 10.1111/j.1462-2920.2009.01963.x

More than just orphans: are taxonomically-restricted genes important in evolution?

Khalturin K, Hemmrich G, Fraune S, Augustin R, Bosch T C (2009); Trends Genet., 25(9):404-13. doi: 10.1016/j.tig.2009.07.006

Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.

Bosch T C, Augustin R, Anton-Erxleben F, Fraune S, Hemmrich G, Zill H, Rosenstiel P, Jacobs G, Schreiber S, Leippe M, Stanisak M, Grötzinger J, Jung S, Podschun R, Bartels J, Harder J, Schröder J M (2009); Dev Comp Immunol., 33(4):559-69. doi: 10.1016/j.dci.2008.10.004

Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra.

Anton-Erxleben F, Thomas A, Wittlieb J, Fraune S, Bosch TC (2009); Zoology (Jena), 112(3):185-94. doi: 10.1016/j.zool.2008.09.002

2007

Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra.

Fraune S, Bosch TCG (2007); Proc Natl Acad Sci USA, 104(32):13146-51. doi: 10.1073/pnas.0703375104

Allorecognition in urochordates: identification of a highly variable complement receptor-like protein expressed in follicle cells of Ciona.

Kurn U, Sommer F, Hemmrich G, Bosch T C, Khalturin K (2007); Dev Comp Immunol., 31(4):360-371. doi: 10.1016/j.dci.2006.06.008

2006

In the urochordate Ciona intestinalis zona pellucida domain proteins vary among individuals.

Kurn U, Sommer F, Bosch T C, Khalturin K (2006); Developmental and comparative immunology, 31(12): 1242-1254. doi: 10.1016/j.dci.2007.03.011

Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis.

Wittlieb J, Khalturin K, Lohmann J, Anton-Erxleben F, Bosch T C G (2006); Proc. Natl. Acad. Sci. USA, 103(16):6208-6211. doi: 10.1073/pnas.0510163103