The comparative method rules! Codon volatility cannot detect positive Darwinian selection using a single genome sequence.
Dagan T, Graur D (2005); Mol Biol Evol., 22(3):496-500. doi: 10.1093/molbev/msi033
Dagan T, Graur D (2005); Mol Biol Evol., 22(3):496-500. doi: 10.1093/molbev/msi033