Contact
Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) Molecular Biology and Evolution, msac018, doi: 10.1093/molbev/msac018
Associated Young Researcher
Dr. Alexander Klimovich
Associated Research Groups
Towards understanding an ultimately simple metaorganism: impact of symbiotic microbes on developmental processes of Hydra
Animal developmental programs occur within the context of coevolved associations with microbes. Hydra is one of the prime model systems for evolutionary developmental biologists. The fact that symbiotic interactions were discovered to be essential to …
Dr. Alexander Klimovich
Publications
Publications
2022
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Featured
The role of DNA methylation in genome defense in Cnidaria and other invertebrates
2021
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Neurons interact with the microbiome: an evolutionary-informed perspective
Giez C, Klimovich A, Bosch TCG (2021) Neuroforum 27(2): 89–98. doi 10.1515/nf-2021-0003
2020
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Featured
Prototypical pacemaker neurons interact with the resident microbiota
2020
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INF
Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.
Rathje K, Mortzfeld B, Hoeppner MP, Taubenheim J, Bosch TCG, Klimovich A (2020) PLoS Pathog. 16(3):e1008375. doi: 10.1371/journal.ppat.1008375
2019
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Featured
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6
2019
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Featured
Transgenesis in Hydra to characterize gene function and visualize cell behaviour.
Klimovich A, Wittlieb J, Bosch TCG (2019) Nat. Protoc., 1-24. doi: 10.1038/s41596-019-0173-3
2018
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Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.
Klimovich AV, Bosch TCG (2018); Bioessays 40(9):e1800060. doi: 10.1002/bies.201800060
2018
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Non-senescent Hydra tolerates severe disturbances in the nuclear lamina.
Klimovich A, Rehm A, Wittlieb J, Herbst EM, Benavente R, Bosch TCG (2018); Aging (Albany NY) 10(5):951-972. doi: 10.18632/aging.101440
2018
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Stem cell transcription factor FoxO controls microbiome resilience in Hydra.
Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629
2017
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Spontaneous body contractions are modulated by the microbiome of Hydra.
Murillo-Rincon A P, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch T C G (2017); Scientific Reports, 7(15937). doi:10.1038/s41598-017-16191-x