Prof. Dr. David Underhill (UCLA & Cedars-Sinai Medical Center, Los Angeles) (online)

As guest of the CRC 1182

Prof. Dr. David Underhill

UCLA Professor In-Residence, Pathology and Laboratory Medicine
Director, Graduate Program in Biomedical Sciences and Translational Medicine, Cedars-Sinai Health System and Research Institute
Associate Director, Dicision of Immunology Research, Biomedical Sciences, Cedar-Sinai Medical Center
Research Scientist, Gastroenterology
Underhill Lab

Talks about:

Innate and Adaptive Immunity to the Mycobiome in Crohn’s Disease

The influence of the intestinal microbiome in health and disease throughout the body is increasingly being recognized. Inflammatory bowel disease (IBD) is characterized by alterations in the intestinal microbiota and altered immune responses to intestinal microbiota. Evidence is accumulating that IBD is influenced not only by commensal bacteria, but also by less well-characterized commensal fungal communities. We have characterized fungi directly associated with the intestinal mucosa in healthy people and in patients with Crohn’s disease and have identified fungi that are specifically abundant in patients. One of these, a common skin resident fungus called Malassezia, is also linked to the presence of an IBD-associated polymorphism in the gene for CARD9, a signaling adaptor protein important for host defense against fungi. Here we discuss this association and evaluate mechanisms of innate and adaptive immune responses to Malassezia.

Register in advance for this Zoom meeting:


Prof. Dr. David Underhill (UCLA & Cedars-Sinai Medical Center, Los Angeles)


September 08th, 2021


Zoom Meeting

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