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Logo CRC 1182 - Origin and Function of Metaorganisms

  • Mission
  • Researchers
  • Research
    • Project Groups
      • Evolution and Ecology
        • A1 | Molecular basis and evolutionary dynamics of C. elegans-microbiota interactions
        • A2 | Host-microbiota coevolution in the mammalian intestine
        • A3 | Domestication-driven metaorganism evolution of wheat
        • A4 | Mathematical modeling of interactions in evolving metaorganisms
      • Recognition and Communication
        • B1 | Host-microbe cross talk in the early metazoan taxa Porifera and anthozoan Cnidaria
        • B2 | Microbiota-host interactions at the base of the metazoan tree
      • Function and Life History
        • C1 | Towards understanding an ultimately simple metaorganism: impact of symbiotic microbes and algae on developmental processes of Hydra and their adaptation within the host
        • C2 | Effects of malnutrition on epithelia-microbe interactions in the intestinal tract of flies and mice
        • C3 | The life cycle of the deep-sea Bathymodiolus metaorganism: symbiont transmission and colonization of the host gill epithelium
      • Science Support
        • Z1 | Administration and coordination of the CRC 1182
        • Z2 | Microorganism: Culture and single cell analysis
        • Z3 | Next generation sequencing applications for studying metaorganisms
        • INF | Data management and integrated analyses
  • Publications
  • Activities
    • CRC 1182 Talks
    • CRC 1182 Metaorganism Seminar
    • CRC 1182 Workshops
    • CRC 1182 Young Investigator Research Day (YIRD)
    • CRC 1182 Retreat
    • CRC 1182 Awards
      • CRC 1182 Young Investigator Award
      • CRC 1182 Lynn Margulis Fund
      • CRC 1182 Karl August Möbius Fellowship
  • News
  • Videos
  • Contact

VIDEOS

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MISSION

From protists to humans, all animals and plants are inhabited by microbial organisms. There is an increasing appreciation that these resident microbes influence fitness of their plant and animal hosts, ultimately forming a metaorganism consisting of a uni- or multicellular host and a community of associated microorganisms.

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Research on host-microbe interactions has become an emerging cross-disciplinary field. In both vertebrates as well as invertebrates a complex microbiome confers immunological, metabolic and behavioural benefits; its disturbance can contribute to the development of disease states. However, the molecular and cellular mechanisms controlling interactions within the metaorganisms are poorly understood and many key interactions between the associated organisms remain unknown.

We are particularly interested in:

  • the specific functional consequences of the interactions,
  • the underlying regulatory principles,
  • and also the resulting impact on host life history and evolutionary fitness in selected host systems.

Holobiont Infografik

Holobiont Infografik

News

July 19th, 2018

50 Years of CRCs: Best Practice in Public Outreach

July 5th, 2018

Press Release: Bestandsaufnahme der Virusforschung (In German)

July 2nd, 2018

Drittes Nachtkonzert im Zoologischen Museum: Impressionen

Young Investigator Research Day 2018

June 26th, 2018

Press Release: Evolution of Metabolic Dependency as Base for Ancestral Symbiosis

June 25th, 2018

Nachtkonzert: Auf musikalischer Reise im Zoologischen Museum

Researchers Participating Institutions All News SciPoster Digital Meta

Research

A1
Project

Molecular basis and evolutionary dynamics of C. elegans-microbiota interactions

The model nematode Caenorhabditis elegans is associated with a distinct microbial community under natural conditions. Yet, to date, the role of the worm’s microbiota for …

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A2
Project

Host-microbiota coevolution in the mammalian intestine

Understanding the forces that shape variation in host-associated bacterial communities within- and between host species is key to understanding the evolution and maintenance of metaorganisms. …

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A3
Project

Domestication-driven metaorganism evolution of wheat

Plants are colonized by a wide diversity of microbes including both eukaryotic and prokaryotic species. Only recently, metagenomic approaches have allowed exhaustive studies of the …

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A4
Project

Mathematical modeling of interactions in evolving metaorganisms

Why do individuals from different taxonomic groups and even kingdoms of life interact with each other within a metaorganism in a generally beneficial way and …

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B1
Project

Host-microbe cross talk in the early metazoan taxa Porifera and anthozoan Cnidaria

The term “metaorganism” was coined in recognition of the fact that in the environment, all multicellular hosts (animals, plants) associate with microorganisms. The concept has …

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B2
Project

Microbiota-host interactions at the base of the metazoan tree

This project addresses in a comparative approach the presence, establishment and functional consequences of microbiota in two basal metazoan animals, the comb jelly Mnemiopsis leidyi …

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C1
Project

Towards understanding an ultimately simple metaorganism: impact of symbiotic microbes and algae on developmental processes of Hydra and their adaption within the host

Inter-species interactions in the freshwater polyp Hydra between symbiotic algae and host cells had been the subject of research since decades since they not only …

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C2
Project

Effects of malnutrition on epithelia-microbe interactions in the intestinal tract of flies and mice

Maintaining the composition of the beneficial intestinal microbiota requires a homeostatic equilibrium between the microbial community and the intestinal epithelium that serves as the regulatory …

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C3
Project

The life cycle of the deep-sea Bathymodiolus metaorganism: symbiont transmission and colonization of the host gill epithelium

Chemosynthetic symbioses evolved independently multiple times in at least nine animal phyla and from at least 12 lineages of free-living bacteria. They were first discovered …

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Z1
Project

Administration and coordination of the CRC 1182

The main purpose of the Z1-project is to bundle the central activities of the Collaborative Research Centre 1182. The administrative office runs the daily affairs …

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Z2
Project

Microorganism: Culture and single cell analysis

The main purpose of the Z2-project is the development of a platform that allows the isolation and identification of microorganisms associated with animal and plant …

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Z3
Project

Next generation sequencing applications for studying metaorganisms

The main purpose of the Z3-project is to provide a standardized central hub for next generation sequencing(NGS)-based applications among CRC 1182 projects. This includes the …

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INF
Project

Data management and integrated analyses

The INF-project is established to support the demanding bioinformatic requirements of the CRC 1182. The project will develop data and metadata standards in order to …

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Research Results

Recent CRC 1182 Publications

Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH and Hülter NF (2018) Front. Microbiol.,  https://doi.org/10.3389/fmicb.2018.00443

Predicted bacterial interactions affect in vivo microbial colonization dynamics in Nematostella

Domin H, Zurita-Gutiérrez Y, Scotti M, Buttlar J, Hentschel Humeida U and Fraune S  (2018) Frontiers in Microbiology 9, 728, https://doi.org/10.3389/fmicb.2018.00728

The C. elegans proteome response to naturally associated microbiome members of the genus Ochrobactrum

Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A (2018); Proteomics, in press, doi: 10.1002/pmic.201700426

The Saposin-Like Protein AplD Displays Pore-Forming Activity and Participates in Defense Against Bacterial Infection During a Multicellular Stage of Dictyostelium discoideum.

Dhakshinamoorthy R, Bitzhenner M, Cosson P, Soldati T, Leippe M (2018); Front. Cell. Infect. Microbiol., 8:73. doi: 10.3389/fcimb.2018.00073

Stem cell transcription factor FoxO controls microbiome resilience in Hydra.

Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., in press

The sponge holobiont in a changing ocean: from microbes to ecosystems.

Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1

All Publications

Contact

Collaborative Research Centre 1182

Speaker:
Prof. Dr. Dr. h.c. Thomas C. G. Bosch
Kiel University
Zoological Institute
Am Botanischen Garten 1-9
D-24118 Kiel

+49 431 880 4170
+49 431 880 4747
tbosch@zoologie.uni-kiel.de

Vice-Speaker:
Prof. Dr. Hinrich Schulenburg
Kiel University
Zoological Institute
Am Botanischen Garten 1-9
D-24118 Kiel

+49 431 880 4143
+49 431 880 2403
hschulenburg@zoologie.uni-kiel.de

Kiel Life Science
Inflammation at Interfaces
Christian-Albrechts-Universität zu Kiel
GEOMAR - Helmholtz Centre for Ocean Research Kiel
Max Planck Institute for Marine Microbiology
Max Planck Institute for Evolutionary Biology
Deutsche Forschungsgemeinschaft
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