On a Western diet, APOEɛ4 is associated with low innate immune sensing, but not APOEɛ3.

Dose J, Schloesser A, Torres GG, Venkatesh G, Häsler R, Flachsbart F, Lieb W, Nebel A, Rimbach G, Huebbe P (2018); J Allergy Clin Immunol. pii: S0091-6749(18)30857-1. doi: 10.1016/j.jaci.2018.05.033