Institution
Felix Sommer was a postdoctoral researcher of the CRC 1182 during the first funding phase. In the second phase he joined the CRC 1182 as Associated Member with his own research project.
Contact
Alumni
Dr. habil. Felix Sommer
Associated Research Groups
Memory mechanisms of nutritional stress in the gut ecosystem
The C2 project focuses on the interaction of nutritional intake with the resident microbiome and the intestinal mucosa. It uses two complementary experimental systems (Drosophila (C2.1, PI Roeder) and mouse (C2.2, PI Rosenstiel)) to tackle …
Dr. habil. Felix Sommer
Publications
Publications
2021
A1
C2
Featured
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.
Hinrichsen F, Hamm J, Westermann M, Schröder L, Shima K, Mishra N, Walker A, Sommer N, Klischies K, Prasse D, Zimmermann J, Kaiser S, Bordoni D, Fazio A, Marinos G, Laue G, Imm S, Tremaroli V, Basic M, Häsler R, Schmitz RA, Krautwald S, Wolf A, Stecher B, Schmitt-Kopplin P, Kaleta C, Rupp J, Bäckhed F, Rosenstiel P, Sommer F (2021) Cell Metab 33(12):2355-2366.e8. doi: 1016/j.cmet.2021.11.004
2020
C2
Nutritional targeting of the microbiome as potential 3 therapy for malnutrition and chronic inflammation
Schröder L , Kaiser S , Flemer B , Hamm J , Hinrichsen F , Bordoni D , Rosenstiel P , Sommer F (2020) Nutrients. 12(10):E3032. doi: 10.3390/nu12103032.
2020
C2
A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine.
von Frieling J, Faisal MN, Sporn F, Pfefferkorn R, Nolte SS, Sommer F, Rosenstiel P, Roeder T (2020) PLoS Genet. 16(5):e1008789. doi: 10.1371/journal.pgen.1008789
2020
A2
C2
Z3
NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation
Moltzau Anderson J, Lipinski S, Sommer F, Pan W-H, Boulard O, Rehman A, Falk-Paulsen M, Stengel ST, Aden K, Häsler R, Bharti R, Künzel S, Baines JF, Chamaillard M, Rosenstiel P (2020) Cell Mol Gastroenterol Hepatol. 10(2): 365-389. doi: 10.1016/j.jcmgh.2020.03.008
2019
A3
A4
B2
C1
C2
INF
Featured
Advancing our functional understanding of host–microbiota interactions: a need for new types of studies
He J, Lange J, Marinos G, Bathia J, Harris D, Soluch R, Vaibhvi V, Deines P, Hassani MA, Wagner K-S, Zapien‐Campos R, Jaspers C, Sommer F (2019) BioEssays, 1900211 (1-5). doi: 10.1002/bies.201900211
2019
C2
The microbiota promotes arterial thrombosis in low-density lipoprotein receptor-deficient mice
Kiouptsi K#, Jäckel S#, Pontarollo G#, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC#, Döring Y#, Reinhardt C (2019) mBio. 10(5). doi: 10.1128/mBio.02298-19. # Contributed equally
2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms
Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1
2018
A2
B2
C1
C2
INF
Z2
Functions of the Microbiota for the Physiology of Animal Metaorganisms
Esser D, · Lange J, · Marinos G, · Sieber M, Best L, Prasse D, Bathia J, Rühlemann MC, Boersch K, Jaspers C, Sommer F (2018) J Innate Immun DOI: 10.1159/000495115
2018
C2
Z3
Featured
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW (2018); Nature 560(7719):489-493. doi: 10.1038/s41586-018-0507-2
2018
A4
C1
C2
Z1
Z3
Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Thomas C. G. Bosch TCG, Roeder T, P Rosenstiel P, Sommer F (2018); Front. Microbiol. doi: 10.3389/fmicb.2018.02020
2018
A2
C2
INF
Z3
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.
Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5
2017
C2
Z3
Featured
The resilience of the intestinal microbiota influences health and disease.
Sommer F, Anderson J M, Bharti R, Raes J, Rosenstiel P (2017); Nat Rev Microbiol., doi: 10.1038/nrmicro.2017.58
2016
A2
C2
INF
Z3
Featured
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695