Principal Investigator

Dr. Sebastian Fraune



12/2005 – 01/2009
Dissertation at the Christian-Albrechts University of Kiel, Zoological Institute, (supervised by Prof. Dr. Dr. h.c. Bosch), Title: Towards understanding a holobiont: Host-microbe interaction in Hydra; “summa cum laude”

1999 – 2005
Diploma Biology (Microbiology, Limnology, Toxicology), Christian-Albrechts University of Kiel, Germany

Research Experience/Academic Appointments

since 2012
Assistant Project Manager for the laboratory of Prof. Bosch to work with genetically-modified organisms (S1)

since 02/2009
Postdoctoral Fellow, Zoological Institute, Christian-Albrechts-University of Kiel, Germany, group of Prof. Dr. Dr. h.c. Thomas Bosch

Important Scientific Prizes/Functions

since 2013
Editorial service for scientific journal: Frontiers in Microbial Symbiosis – Associate Editor

since 2012
Referee service for scientific journals: Environmental Microbiology, PLoS ONE, Marine Biology, Bioessays, Frontiers in Microbial Symbiosis

Awards: Poster Prize, Gordon Research Conference Antimicrobial Peptides in Innate Immunity – New Insights on an Ancient System

Travel grant to participate at the 2nd ASM Conference on Beneficial Microbes, San Diego (USA)




Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122

Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH and Hülter NF (2018) Front. Microbiol.

Predicted bacterial interactions affect in vivo microbial colonization dynamics in Nematostella

Domin H, Zurita-Gutiérrez Y, Scotti M, Buttlar J, Hentschel Humeida U and Fraune S  (2018) Frontiers in Microbiology 9, 728,

Stem cell transcription factor FoxO controls microbiome resilience in Hydra.

Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., in press

Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?

Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004


Temperate phages as self-replicating weapons in bacterial competition.

Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563

FeaturedA secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1

Temperate phages as frequency-dependent weapons in bacterial competition.

Li X Y, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); j r soc interface, doi: 10.1101/185751


Emerging Sponge Models of Animal-Microbe Symbioses.

Pita L, Fraune S, Hentschel U (2016); Front Microbiol., 7:2102. doi: 10.3389/fmicb.2016.02102

Using Nematostella vectensis to Study the Interactions between Genome, Epigenome, and Bacteria in a Changing Environment.

Fraune S, Forêt S, Reitzel A M (2016); Front. Mar. Sci., 3:148. doi: 10.3389/fmars.2016.00148