Principal Investigator

Prof. Dr. Andre Franke

Vita

Education/Training

2004 – 2006
PhD work at CAU under supervision of Profs. Stefan Schreiber: “A systematic genome-wide association analysis for inflammatory bowel diseases”

2002 – 2003
Diploma thesis at the laboratory of Prof. Thomas C.G. Bosch at CAU: “Development of a high-throughput screening for identification of developmentally regulated genes in Hydra”

1998 – 2002
Study of Biology and Informatics at CAU


Research Experience/Academic Appointments

Since 2016
W3 professorship of Molecular Medicine

Since 2011
Director of the Institute of Clinical Molecular Biology

2011 – 2016

W2 endowment professorship “Peter Hans-Hofschneider”of the Foundation of Experimental Biomedicine (Zuerich, Switzerland)

2011
Guest scientists at the Broad Institute of MIT and Harvard (Boston, USA) in the group of Mark J. Daly and mentored by Richard S. Blumberg

2008 – 2013
Academic guest professorship at the Medical Faculty, University of Oslo, Norway (Rikshospitalet)

2008 – 2011
W1 junior professorship for Epithelial Barrier Diseases within the DFG Cluster of Excellence “Inflammation at Interfaces”


Important Scientific Prizes/Functions

Since 2012
Spokesperson of the DFG Research Training Group GRK1743/1 “Genes, Environment and Inflammation”

Since 2012
Member of the Steering Committee of “Inflammation at Interfaces”; Leader of Research Area I (Genetics)

2017
Schleswig-Holstein Excellence Chair (8 professors in State selected)

2017
Thannhauser Prize of the DGVS

2012
Ludwig-Demling Research Prize of German Crohn’s and Colitis Foundation (DCCV); 25,000 €

2011
Janssen Prize Dermatology

2009 – 2012
Spokesperson of the young investigators of the Excellence Cluster “Inflammation at Interfaces”

2008
Hensel Prize (100,000 €) for Excellent Research of CAU Kiel

Associated Research Groups

Data management and integrated analyses

The INF-project supports the demanding data handling and bioinformatic requirements of the CRC. As one of its main objectives, the project facilitates data management through aggregation of metadata and centralized, redundant storage in collaboration with

Prof. Dr. Andre Franke
Publications

Publications

Filter by

Year All
2020
A2

Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species

Rühlemann MC, Solovjeva MEL, Zenouzi R, Liwinski T, Kummen M, Lieb W, Hov JR, Schramm C, Franke A# , Bang C# (2020) Gut 69 (10), 1890-1892 # Contributed equally doi: 10.1136/gutjnl-2019-320008
2020
A2

Genome-wide associations of human gut microbiome variation and implications for causal inference analyses

Hughes DA, Bacigalupe R, Wang J, Rühlemann MC, Tito RY, Falony G, Rymenans L, Verspecht C, Ring S, Franke A, Wade KH, Timpson NJ, Raes J (2020) Nat Microbiol 5, 1079–1087. doi: 10.1038/s41564-020-0743-8
2020
A2

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

Liwinski T, Casar C, Ruehlemann MC, Bang C, Sebode M, Hohenester S, Denk G, Lieb W, Lohse AW, Franke A, Schramm C (2020) Aliment Pharmacol Ther. 51(12):1417-1428. doi: 10.1111/apt.15754
2020
A2
A3

A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition

Seybold H, Demetrowitsch TJ, Hassani M A, Szymczak S, Reim E, Haueisen J, Lübbers L, Rühlemann M, Franke A, Schwarz k, H. Stukenbrock E (2020) Nature Communications. 11(1):1910. doi: 10.1038/s41467-020-15633-x

2020
A2

Alterations of the bile microbiome in primary sclerosing cholangitis

Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C,  Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JH, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2020) Gut 69 (4), 665-672 doi: 10.1136/gutjnl-2019-318416
2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1

2019

Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F (2019) Cell 178(6): 1299–1312. doi: 10.1016/j.cell.2019.08.003

2019
A2

Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis

Rühlemann M, Liwinski T, Heinsen F-A, Bang C, Zenouzi R, Kummen M, Thingholm L, Tempel M, Lieb W, Karlsen T, Lohse A, Hov J, Denk G, Lammert F, Krawczyk M, Schramm C, Franke A (2019) Aliment Pharmacol Ther. 1-10. doi: 10.1111/apt.15375

2019
A2

Alterations of the bile microbiome in primary sclerosing cholangitis

Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2019) Gut 0:1–8. doi:10.1136/gutjnl-2019-318416

2018
A2
C2

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018) Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5.
2018
A2
C2
INF
Z3

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5

2018
A2
B1
INF
Z2

The sponge holobiont in a changing ocean: from microbes to ecosystems.

Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1

2018
A2

Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration

Baurecht H, Rühlemann M, Rodríguez E, Thielking F, Harder I, Erkens AS, Stölzl D, Ellinghaus E, Hotze M, Lieb W, Wang S, Heinsen FA, Franke A, Weidinger S (2018) J ALLERGY CLIN IMMUN . doi: 10.1016/j.jaci.2018.01.019

2018
A2
C2
INF
Z3

The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.

Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner J T, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen F A, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome., 6(1):37. doi: 10.1186/s40168-018-0414-7

2017
A2
Z3

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.

Rühlemann M C, Degenhardt F, Thingholm L B, Wang J, Skiecevičienė J, Rausch P, Hov J R, Lieb W, Karlsen T H, Laudes M, Baines J F, Heinsen F A, Franke A (2017); Gut Microbes., 8:55. doi: 10.1080/19490976.2017.1356979

2016
A2
C2
INF
Z3

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695

Institutions & Partners

By continuing to use the site, you agree to the use of cookies and our privacy policy.