Principal Investigator

Prof. Dr. Andre Franke

Institution

Kiel University Institute of Clinical Molecular Biology

Contact


Vita

Education/Training

2004 – 2006
PhD work at CAU under supervision of Profs. Stefan Schreiber and Bosch: “A systematic genome-wide association analysis for inflammatory bowel diseases”

2002 – 2003
Diploma thesis at the laboratory of Prof. Thomas C.G. Bosch at CAU: “Development of a high-throughput screening for identification of developmentally regulated genes in Hydra”

1998 – 2002
Study of Biology and Informatics at CAU


Research Experience/Academic Appointments

2011
Guest scientists at the Broad Institute of MIT and Harvard (Boston, USA) in the group of Mark J. Daly and mentored by Richard S. Blumberg Since 2011 W2 endowment “Peter Hans-Hofschneider” professorship of the Foundation of Experimental Biomedicine (Zuerich, Switzerland)

Since 2011
Director of the Institute of Clinical Molecular Biology

2008 – 2013
Academic guest professorship at the Medical Faculty, University of Oslo, Norway (Rikshospitalet)

2008 – 2011
W1 junior professorship for Epithelial Barrier Diseases within the DFG Cluster of Excellence “Inflammation at Interfaces”


Important Scientific Prizes/Functions

2012
Ludwig-Demling Research Prize of German Crohn’s and Colitis Foundation (DCCV); 25,000 €

Since 2012
Spokesperson of the DFG Research Training Group GRK1743/1 “Genes, Environment and Inflammation”

Since 2012
Member of the Steering Committee of “Inflammation at Interfaces”; Leader of Research Area I (Genetics)

2011
Janssen Prize Dermatology

2011
Peter Hans-Hofschneider endowment professorship

2009 – 2012
Spokesperson of the young investigators of the Excellence Cluster “Inflammation at Interfaces”

2008
100,000 € Hensel Prize for Excellent Research of CAU Kiel

Research

Publications

2018

The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.

Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner JT, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen FA, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome. 6(1):37. doi: 10.1186/s40168-018-0414-7

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5

The sponge holobiont in a changing ocean: from microbes to ecosystems.

Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1

The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.

Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner J T, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen F A, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome., 6(1):37. doi: 10.1186/s40168-018-0414-7

2017

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.

Rühlemann M C, Degenhardt F, Thingholm L B, Wang J, Skiecevičienė J, Rausch P, Hov J R, Lieb W, Karlsen T H, Laudes M, Baines J F, Heinsen F A, Franke A (2017); Gut Microbes., 8:55. doi: 10.1080/19490976.2017.1356979

2016

FeaturedGenome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695