Principal Investigator

Prof. Dr. Andreas Tholey

Vita

Education/Training

2007
Habilitation for Analytical Biochemistry (Univ. d. Saarlandes)

1999
Dr. rer.nat (University of the Saarlands / DKFZ Heidelberg)

1995
Dipl. Chem. (University of the Saarlands)

1989 – 1995
Study of Chemistry, University of the Saarland, Saarbrücken, Germany


Research Experience/Academic Appointments

2010
Guest-professorship at Université de Pau, France

since 2008
Group leader and W2-professor for Systematic Proteome Research & Bioanalytics at the Christian-Albrechts-University of Kiel (position originally funded via DFG-Cluster of Excellence “Inflammation at Interfaces”; now: permanent position)

2004
Research Stage at the “Laboratoire de Spectrometrie de masse Bio-Organique”, University of Strasbourg/ CNRS, Strasbourg, France

1999 – 2007
Postdoctoral fellow and Habilitation (C1), University of the Saarland

1995 – 1998
Scientific assistant, German Cancer Research Centre (DKFZ), Heidelberg


Important Scientific Prizes/Functions

since 2012
Member of the Steering-Committee of the DFG-Cluster of Excellence-308 “Inflammation at Interfaces”

since 2011
Vice-chair of initiative on multi-organism proteomics (iMOP) within human proteome organization (HUPO)

Research

Publications

2018

The Caenorhabditis elegans Proteome Response to Naturally Associated Microbiome Members of the Genus Ochrobactrum.

Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A. (2018); Proteomics. 18(8):e1700426. doi: 10.1002/pmic.201700426

Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors.

Leipert J, Bobis I, Schubert S, Fickenscher H, Leippe M, Tholey A (2018); Anal Bioanal Chem. , pp 1–12. doi: 10.1007/s00216-018-0937-6

2017

We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project.

Tholey A, Taylor N L, Heazlewood J L, Bendixen E (2017); J Proteome Res., 16(12):4273-4280. doi: 10.1021/acs.jproteome.7b00408

Insights into Microalga and Bacteria Interactions of Selected Phycosphere Biofilms Using Metagenomic, Transcriptomic, and Proteomic Approaches.

Krohn-Molt I, Alawi M, Förstner K U, Wiegandt A, Burkhardt L, Indenbirken D, Thieß M, Grundhoff A, Kehr J, Tholey A, Streit W R (2017); Front Microbiol., doi: 10.3389/fmicb.2017.01941

Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

Leipert J, Treitz C, Leippe M, Tholey A (2017); J Am Soc Mass Spectrom., 28(12):2538-2547. doi: 10.1007/s13361-017-1777-x

FeaturedEfficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection. Gastroenterology.

Ott S J, Waetzig G H, Rehman A, Moltzau-Anderson J, Bharti R, Grasis J A, Cassidy L, Tholey A, Fickenscher H, Seegert D, Rosenstiel P, Schreiber S (2017); Gastroenterology, 152(4):799-811.e7. doi: 10.1053/j.gastro.2016.11.010

2016

Differential quantitative proteome analysis of Escherichia coli grown on acetate versus glucose.

Treitz C, Enjalbert B, Portais J C, Letisse F, Tholey A (2016); Proteomics., 16(21):2742-2746. doi: 10.1002/pmic.201600303

Combination of Bottom-up 2D-LC-MS and Semi-top-down GelFree-LC-MS Enhances Coverage of Proteome and Low Molecular Weight Short Open Reading Frame Encoded Peptides of the Archaeon Methanosarcina mazei.

Cassidy L, Prasse D, Linke D, Schmitz R A, Tholey A (2016)
J Proteome Res., 15(10):3773-3783. doi: 10.1021/acs.jproteome.6b00569