Dr. Andreas Diepold (MPI, Marburg) (online)
As guest of the CRC 1182 (host: Daniel Unterweger)
Dr. Andreas Diepold
Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Research group: Bacterial Secretion Systems
The type III secretion system – a dynamic and versatile protein syringe for bacterial-eukaryotic interaction
To survive in contact to eukaryotic cells, many bacteria employ the type III secretion system, a molecular syringe, to inject proteins into their host cells. The resulting manipulation of host cell behaviour is essential for different forms of bacterial-eukaryotic interaction – from symbiosis to some of the most notorious human diseases. My group wants to understand the function and regulation of the type III secretion system. Studying the system in live Yersinia enterocolitica, a human gastrointestinal pathogen, both in isolation and in contact to host cells, we have found that parts of the type III secretion system are dynamic: they constantly exchange between the machinery and a cytosolic pool during the function of the system. Our new results reveal that this dynamic behavior helps to adapt the system to changing external conditions and needs of the bacteria. In the talk, I will present the basics of type III secretion, some of our most interesting new findings, as well as applications of protein dynamics in bacteria.
Register in advance for this Zoom meeting:
November 09th, 2020