Principal Investigator, Steering Committee

Prof. Dr. Dr. h.c. Thomas C.G. Bosch

Institution

Kiel University
Zoological Institute
Cell and Developmental Biology Lab
Vita

Education/Training

1986 – 1988
Post-Doc – Feodor Lynen fellow of Alexander-von-Humboldt Foundation at the Developmental Biology Center, University of California, Irvine, USA

1983 – 1986
Doctoral student, Zoological Institute, University of Munich

1976 – 1983
Study of Biology at University of Munich, Germany, and University College Swansea, UK.

Research Experience/Academic Appointments

Since 2000
Professor (C4) „Allgemeine Zoologie“ at the Christian-Albrechts-University Kiel

1997 -1999
Professor (C3) „Spezielle Zoologie“ at the Friedrich-Schiller University Jena

1993 -1997
Junior Faculty (Oberassistent, Privatdozent C2), Zoological Institute, University of Munich

1988 – 1993
Research Assistant, Zoological Institute, University of Munich

Important Scientific Prizes/Functions

Since 2016
Speaker of the CRC 1182 “Origin and Function of Metaorganisms”

Since 2016
Member of Expert Council for the “Biology” Programmes, St. Peterburg State University, Russia

Since 2015
Fellow at the Canadian Institute for Advanced Studies (CIFAR)

Since 2015
Speaker, wissenschaftlicher Fakultätsbeirat der Universität Jena

Since 2015
Member, Wissenschaftlicher Beirat für Programm-Evaluation der Alexander von Humboldt Stiftung

Since 2013
Speaker of the University Research Focus “”Kiel Life Science” (KLS)

Since 2013
Member Advisory Board, Stiftung Old Herborn University, Institut für Integrative Biologie Herborn an der Dylle

Since 2012
Member and speaker (since 2015) of DFG Review Board 203 Zoology (DFG-Fachkollegium 203 Zoologie)

Since 2008
Editor in Chief, Zoology (Elsevier)

2018/2019
Fellow at the Wissenschaftskolleg (Institute of Advanced Studies) zu Berlin

2018
Kane Memorial Lecturer, University of Hawaii, USA

2016/2017
President Deutsche Gesellschaft für Entwicklungsbiologie (GfE)

2016
Peter Hemmerich Vorlesung, Universität Konstanz

2011, 2016
Member, Selection Committee for International Prize for Biology JSPS, Tokyo

2015/2016
Deputy President Deutsche Zoologische Gesellschaft (DZG)

2014
Koshland Lecture Award, University of Chicago, USA

2010-2013
Vice President of Christian-Albrechts-University Kiel

2010
Carl-Friedrich-von-Siemens Foundation Lecture, Munich

2006-2014
Mitglied im Auswahlausschuss der Alexander-von-Humboldt-Stiftung zur Vergabe der Feodor-Lynen Stipendien

2004
Doctor „honoris causa“ from St. Petersburg State University, Russian

 

Contact

+49 431 880 4169
+49 431 880 4747
tbosch@zoologie.uni-kiel.de
https://www.bosch.zoologie.uni-kiel.de/ https://gepris.dfg.de/gepris/person/1009942

Associated Research Groups

PR

Communicating the Metaorganism

For the CRC, science communication is much more than informing the public. We consider science communication as an interaction between science and various public stakeholders, and as a multi-cultural learning experience. Our objective is to …

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Prof. Dr. Dr. h.c. Thomas C.G. Bosch
Publications

Publications

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Year All
2024
C1

Satiety controls behavior in Hydra through an interplay of pre-enteric and central nervous system-like neuron populations

Giez, C., Noack, C., Sakib, E., Hofacker, L. M., Repnik, U., Bramkamp, M., & Bosch, T. C. (2024). Cell Reports, 43(6). doi: https://doi.org/10.1016/j.celrep.2024.114210

2024
C1
Featured

The potential importance of the built-environment microbiome and its impact on human health

Bosch, T. C., Wigley, M., Colomina, B., Bohannan, B., Meggers, F., Amato, K. R., Azad, M. B., Blaser, M. J., Brown, K., Dominguez-Bello, M. G., Ehrlich, S. D., Elinav, E., Finlay, B., Geddie, K., Geva-Zatorsky, N., Giles-Vernick, T., Gros, P., Guillemin, K., Haraoui, L. P., Johnson, E., Keck, F., Lorimer, J., McFall-Ngai, M. J., Nichter, M., Petterson, S., Poinar, H., Rees, T., Tropini, C., Undurraga, E. A., Zhao, L., & Melby, M. K. (2024). Proceedings of the National Academy of Sciences, 121(20), e2313971121. doi: https://doi.org/10.1073/pnas.2313971121

2024
PR.1
PR.2
PR.3
A1
C1

Wie arbeitet Wissenschaft heute? Vernetzte Zugänge für Universität und Schule

Parchmann, I., Bosch, T. B., Claussen, C., Duscher, T., Enzingmüller, C., Knüver, J., & Schulenburg, H. (2024). MNU-Journal/Verband zur Förderung des MINT-Unterrichts, 2024(1), 29-36.

2024
C4

The archaeome in metaorganism research, with a focus on marine models and their bacteria–archaea interactions

von Hoyningen-Huene, A. J., Bang, C., Rausch, P., Rühlemann, M., Fokt, H., He, J., Jensen, N., Knop, M., Petersen, C., Schmittmann, L., Zimmer, T., Baines, J. F., Bosch, T. C. G., Hentschel, U., Reusch, T. B. H., Roeder, T., Franke, A., Schulenburg, H., Stukenbrock, E., & Schmitz, R. A. (2024). Frontiers in Microbiology, 15, 1347422. doi: https://doi.org/10.3389/fmicb.2024.1347422

2023
PR.2
PR.3
A1

Meet the Metaorganism: A web‐based learning app for undergraduate and graduate biology students

Landis, S. H., Piecyk, A., Reitz, M., Enzingmüller, C., Schulenburg, H., Bosch, T., Dierking, K.,  Deines, P., Hunfeld-Häutle, J., Rappaport, K., & Duscher, T. (2023). BioEssays, 45(10), 2300043. doi: https://doi.org/10.1002/bies.202300043

2023
C1

Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations

Nawroth JC, Giez C, Klimovich A, Kanso EA, Bosch TCG (2023) Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations. eLife doi: 10.7554/eLife.83637.

2023
C1

Microbes as part of ancestral neuronal circuits: Bacterial produced signals affect neurons controlling eating behavior in Hydra.

Giez C, Pinkle D, Giencke Y, Wittlieb J, Herbst E, Spratte T, Lachnit T, Klimovich A, Selhuber-Unkel C,  Bosch TCG (2023) Microbes as part of ancestral neuronal circuits: Bacterial produced signals affect neurons controlling eating behavior in Hydra.  bioRxiv  doi: 10.1101/2023.04.28.538719

 

2022
C1

Beyond Lynn Margulis’ green hydra

Bosch, T. C. (2022). Symbiosis, 87(1), 11-17.

2022
B1
C1
C4

Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.

Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Front. Microbiol. 13:869666. doi: 10.3389/fmicb.2022.869666

2022
B1
C1

Symbiont transmission in marine sponges: reproduction, development, and metamorphosis

Carrier TJ, Maldonado M, Schmittmann L, Pita L, Bosch TCG, Hentschel U (2022) BMC Biology 20(1):100 doi: 10.1186/s12915-022-01291-6

2022
C1

Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen

Bosch T & Giez C (2022). Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen. Biologie in Unserer Zeit, 52(4), 352–362. https://doi.org/10.11576/biuz-5866

2022
C1

Hydra´s lasting partnership with microbes: key for escaping senescence?

He J, Bosch TCG (2022) Microorganisms 10(4):774. doi: 10.3390/microorganisms10040774

2022
C1
C4

Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont.

Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCG (2022 ) Bioessays. 44(5):e2100233. doi: 10.1002/bies.202100233.

2022
B1
C1
Featured

The role of DNA methylation in genome defense in Cnidaria and other invertebrates

Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) Molecular Biology and Evolution, msac018, doi: 10.1093/molbev/msac018

2021
C1

Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome

Bosch TCG, Zasloff M (2021) mBio. 12(5):e01847-21. doi: 10.1128/mBio.01847-21

2021
PR
Featured

Making the invisible visible: exploring host–microbiome interactions across different taxa using data-driven 3D visualization

Landis SH, Duscher T, Bosch TCG (2021) Biochem (Lond) bio_2021_164. doi: 10.1042/bio_2021_164

2021
C1
Featured

Taking a microscale look at symbiotic interactions—and why it matters

Bosch TCG (2021) PNAS. 118 (31) e2110874118. doi: 10.1073/pnas.2110874118

2021
C1
Featured

Beating in on a stable partnership.

Giez C, Bosch TCG (2021) Nat Rev Microbiol. doi: 10.1038/s41579-021-00575-y

2021
C1

Neurons interact with the microbiome: an evolutionary-informed perspective

Giez C, Klimovich A, Bosch TCG (2021) Neuroforum 27(2): 89–98. doi 10.1515/nf-2021-0003

2021
C1

Animal development in the microbial world: Re-thinking the conceptual framework. 

Bosch TCG and McFall-Ngai M (2021) Current Topics in Developmental Biology. 141:399-427. ISSN 0070-2153. doi: 10.1016/bs.ctdb.2020.11.007

2021
C1

Animal development in the microbial world: The power of experimental model systems.

McFall-Ngai M and Bosch TCG (2021) Current Topics in Developmental Biology. 141: 371-397. ISSN 0070-2153. doi: 10.1016/bs.ctdb.2020.10.002

2021
C1
Featured

The hygiene hypothesis, the COVID pandemic, and consequences for the humanmicrobiome

Finlay BB, Amato KR, Azad M, Blaser MJ, Bosch TCG, Chu H, Dominguez-Bello MG, Ehrlich SD, Elinav E, Geva-Zatorsky N, Gros P, Guillemin K, Keck F, Korem T, McFall-Ngai MJ, Melby MK, Nichter M, Pettersson S, Poinar H, Rees T, Tropini C, Zhao L, Giles-Vernick T (2021) PNAS. 118 (6) e2010217118. doi: 10.1073/pnas.2010217118

2020
B1
C1
Featured

Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra

Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) PNAS. 117(35):21459-21468. doi: 10.1073/pnas.2010945117

2020
C1

Exploring the niche concept in a simple metaorganism

Deines P, Hammerschmidt K, TCG Bosch (2020) Frontiers in Microbiology, 11:1942, 1-11. doi: 10.3389/fmicb.2020.01942 

2020
C1

Microbial species coexistence depends on the host environment

Deines P, Hammerschmidt K, Bosch TCG (2020) mBio 11:e00807-20. doi: 10.1128/mBio.00807-20.

2020
C1
Featured

Prototypical pacemaker neurons interact with the resident microbiota

Klimovich A, Giacomello S, Björklund Å, Faure L, Kaucka M, Giez C, Murillo-Rincon AP, Matt A, Willoweit-Ohl D, Crupi G, de Anda J, Wong GCL, D’Amato M, Adameyko I, Bosch TCG (2020) PNAS. 117 (30) 17854-17863. doi: 10.1073/pnas.1920469117

2020
C1
INF

Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.

Rathje K, Mortzfeld B, Hoeppner MP, Taubenheim J, Bosch TCG, Klimovich A (2020) PLoS Pathog. 16(3):e1008375. doi: 10.1371/journal.ppat.1008375

2020
C1
Featured

Are noncommunicable diseases communicable?

Finlay BB,  Blaser MJ, Bosch TCG, Dominguez-Bello MG, Elinav E, McFall-Ngai M, Melby MK, Muehlmann SR,  Sansonetti PJ (2020) Science. 367(6475): 250-251. doi: 10.1126/science.aaz3834 

2020
A4
B1

Bdellovibrio and like organisms are predictors of microbiome diversity across diverse host groups.

Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2020) Microbial Ecology. 79: 252–257. doi: 10.1007/s00248-019-01395-7

2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1

2019
A4
B1
C1
C2
Featured

Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6

2019
A2
A4
B1
B2
Featured

Neutrality in the metaorganism

Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A (2019) PLoS Biol., DOI: 10.1371/journal.pbio.3000298

2019
C1
Featured

Transgenesis in Hydra to characterize gene function and visualize cell behaviour.

Klimovich A, Wittlieb J, Bosch TCG (2019) Nat. Protoc., 1-24. doi: 10.1038/s41596-019-0173-3

2019
A4
C1

The microbiome mediates environmental effects on ageing

Finlay B, Pettersson S, Melby M, Bosch TCG (2019) BioEssays, 1800257, 1-7; doi: 10.1002/bies.201800257

2019
A4
C1

Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions

Bosch TCG, Guillemin K, McFall-Ngai M (2019) BioEssays, 1800256 (1-8). doi: 10.1002/bies.201800256

2019
A4

Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective.

Lachnit T, Bosch TCG, Deines P (2019) mBio (Opinion article); 10:3, e00355-19, 1-8, doi: 10.1128/mBio.00355-19

2019
A4
B1
B2

Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches

Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Zoology. doi: 10.1016/j.zool.2019.02.007

2018
A4
C1
Z1

Hydra as Model to Determine the Role of FOXO in Longevity

Bosch TCG (2018); Methods Mol Biol. 1890:231-238. doi: 10.1007/978-1-4939-8900-3_19

2018
A4
B1
C1
Z1

Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122

2018
A4
C1
C2
Z1
Z3

Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy

Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Thomas C. G. Bosch TCG, Roeder T, P Rosenstiel P, Sommer F (2018); Front. Microbiol. doi: 10.3389/fmicb.2018.02020

2018
A4
C1
Z1

Non-senescent Hydra tolerates severe disturbances in the nuclear lamina.

Klimovich A, Rehm A, Wittlieb J, Herbst EM, Benavente R, Bosch TCG (2018); Aging (Albany NY) 10(5):951-972. doi: 10.18632/aging.101440

2018
A4
C1
Z1

Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.

Klimovich AV, Bosch TCG (2018); Bioessays 40(9):e1800060. doi: 10.1002/bies.201800060

2018
A3
C1

Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH and Hülter NF (2018) Front. Microbiol.,  https://doi.org/10.3389/fmicb.2018.00443

2018
A4
B1
C1
Z1

Stem cell transcription factor FoxO controls microbiome resilience in Hydra.

Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629

2018
A1
A2
A3
A4
B1
B2
C1
Z1

Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?

Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004

2018
A4
C1
Z1

How the microbiome challenges our concept of self.

Rees T, Bosch T G C, Douglas A E (2018); PloS Biol., 16(2):e2005358. doi:10.1371/journal.pbio.2005358

2017
A4
B1
C1
Z1

Temperate phages as self-replicating weapons in bacterial competition.

Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563

2017
A4
C1
Z1

Spontaneous body contractions are modulated by the microbiome of Hydra.

Murillo-Rincon A P, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch T C G (2017); Scientific Reports, 7(15937). doi:10.1038/s41598-017-16191-x

2017
A4
B1
C1
Z1
Featured

A secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1

2016
A4
C1
Z1

The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra.

Schröder K, Bosch T C (2016); MBio., 7(6):e01184-16. doi: 10.1128/mBio.01184-16

2016
A4
C1
Z1

Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model.

Deines P, Bosch T C G (2016); Front. Microbiol., 7:1610. doi: 10.3389/fmicb.2016.01610

Institutions & Partners